A Real Guide to the Best 7-Hydroxymitragynine Dose and Kratom Use for Rewarding Effects

More and more people are turning to 7-hydroxymitragynine. It is, after all, the most relaxing and relieving of kratom's alkaloids. But what is the optimal 7-hydroxymitragynine dose for fast and long-lasting relief? While it may vary a bit from person to person, we do have some guidelines and tips for you.

Today, Real Botanicals discusses the unique relationship between mitragynine and 7-hydroxymitragynine, and what 7-hydroxymitragynine dose is best for strong relief. 

Mitragynine vs 7-Hydroxymitragynine

The two main alkaloids in Mitragyna speciosa (kratom leaf from Southeast Asia) are mitragynine and 7-hydroxymitragynine. Mitragynine is the abundant indole alkaloid in kratom that may help lift your mood, improve stamina, and help you navigate stress pitfalls. Users agree, the effect of mitragynine is undeniably pleasant. 

However, there are other important alkaloids, including 7-hydroxymitragynine.

Despite its trace abundance, 7-hydroxymitragynine (also called 7-OH) plays a disproportionately large role in kratom's effects, especially max relief and relaxation. Tap into this wellspring, and you may have your most impactful kratom experience yet! 

It's due to the unique chemical properties of 7-hydroxymitragynine and how it works in the body. 

Pharmacology of 7-Hydroxymitragynine 

Kratom's potential for pain relief comes from the purported analgesic qualities of some of the alkaloids present in kratom, primarily 7-hydroxymitragynine. But how does it work? Here's a breakdown of its chemical makeup and impact on the body. Does it really have more potency than morphine? What about drug withdrawal?

Let's take a closer look.

7-Hydroxymitragynine Chemical Structure & Interaction 

Initially, the combined effects of mitragynine and 7-hydroxymitragynine were obtained when fresh kratom leaves were chewed. Today, a variety of kratom products are available on the market, including 7-hydroxymitragynine ones, which are evolving our understanding of kratom use. Expanding it into new therapeutic territories. Many advanced kratom users are convinced of its use for chronic pain or overwhelming stress, but the scientific jury is still out on these points.

For all you science people out there - 7-Hydroxymitragynine differs structurally from the indole-based alkaloid mitragynine in that it contains a hydroxyl group (-OH) at the 7-position of the indole ring. This explains the naming 7 + hydroxymitragynine.

This structure increases the affinity at your body's receptors, providing substantially stronger effects. 

Alkaloid 7-Hydroxymitragynine Receptor Activities 

• μ-opioid receptor (MOR): A partial agonist at the μ-opioid receptor. Higher affinity than mitragynine (MIT) and even morphine at this receptor. Effects are estimated at 30-40x more potent than MIT for analgesia effects. 

• δ-opioid (DOR) and κ-opioid (KOR) receptors: Minimal activity compared to MOR; 7-OH has limited binding or efficacy at these receptors.

• Non-opioid receptors: 7-OH shows little or no significant activity at adrenergic, serotonergic, or dopaminergic receptors, unlike mitragynine, which has broader pharmacology.

Thanks to 7-hydroxymitragynine's unique chemical makeup, we may experience opioid-like effects without the opioids.

Is 7-Hydroxymitragynine an Opioid? (7-OH Myth #1)

No, it's not. People often use morphine as a reference point. By comparing it to the known potency of something familiar, like morphine or other opiate medications, people can get an idea of 7-OH's strength. But kratom and its alkaloids are not related to opium-derived substances. That being said, alkaloid antinociceptive and weak rewarding effects are often unfairly compared to opiates. 

Is 7-OH an Opioid Addiction Treatment? (7-OH Myth #2)

Not officially, no. Though some people claim it was helpful in their self-treatment of opioid withdrawal. This use hasn't been scientifically proven to be effective or safe. Reputable kratom vendors will not advise this practice without medical supervision.

7-Hydroxymitragynine Effects 

These targeted interactions between 7-hydroxymitragynine and your body's mu-opioid receptors are particularly strong, targeting significant relief. This means the 7-OH kratom alkaloid is perfect for particular applications:

Pain Modulation

By working as an analgesic, 7-OH delivers nearly all of the antinociceptive qualities of kratom. While analgesic properties reduce pain perception, antinociceptive qualities can block pain signaling. Both can provide notable relief for the kratom user who needs this level of support. 

Relaxation

7-OH effects on stress modulation are also related to its strong action at the opioid receptors. Activation of MOR reduces neuronal excitability and dampens the body's stress response. Therefore, you feel deeply relaxed.

Mitragynine to Metabolite 7-Hydroxymitragynine

Naturally, 7-OH appears in kratom leaf at approximately 2% or less of the total alkaloid content. But, 7-OH is also formed as an active metabolite of mitragynine in the liver (via enzyme CYP3A4). Mitragynine is credited with some analgesic effects that may be partially dependent on its biotransformation to 7-OH.

Direct ingestion of isolated and extracted 7-OH results in more intense relaxation and relief effects. Because of its strength, getting the correct 7-hydroxymitragynine dose is essential. 

What Are 7-Hydroxymitragynine Products?

Real Botanicals recognized early that some kratom users need higher levels of relief than others. The question then became—How can we address this while staying true to our commitment to you, providing only natural, fresh kratom options?

The answer to this was our proprietary ChromaPure extraction method, which allowed us to carefully extract pure 7-hydroxymitragynine molecules without damaging or altering them. The ChromaPure process is painstaking, but worth it, to produce high 7-OH products to address discomfort with the use of kratom.

We use only fresh kratom leaves in our production process, which supplies ample amounts of alkaloids. Especially the revered 7-hydroxymitragynine, more impactful and potent than mitragynine, and products enhanced with MIT only.

To reduce the potential for abuse, getting the right doses of 7-hydroxymitragynine is paramount to your continued success in how kratom is used per dose and per day.

Dosing Guide to 7-Hydroxymitragynine Products

You don't need a very high dose of 7-hydroxymitragynine. If you are accustomed to taking pure MIT products, the acute effects are often tied to taking several grams, or 4-6 pills. This is not the case with 7-hydroxymitragynine products.

Personal evaluation of the rewarding effects will help you determine your sweet spot 7-hydroxymitragynine dose. While there are no set standards on the correct dosing of 7-hydroxymitragynine, we've provided some guidelines below.  

We have two strong types of 7-Hydroxy products for sale, available in higher doses, so you can cut down to the dosage that's best for you. 

7-Hydro Chewable Tablets

Chewable tablets bring ease and convenience to your 7-OH kratom dosing experience. Our 7-Hydro chewables are easily divided into smaller pieces so you can control the amount of 7-hydroxymitragynine you take. Kratom effects are higher, more tailored toward relaxation, and can provide significant relief for those who need it.

Beginners to 7-OH

Not recommended. Try starting with our kratom capsules or kratom and kava shots for a smooth solution to everyday uses! 

Moderate Users of Kratom Extracts

¼ of a tablet, which is 2.5 mg.
Once daily, with breaks to prevent tolerance.

Experienced Users of High-Strength Kratom Tablets

Moderate: 2.5-5mg of 7-OH, achievable by:

• ¼ 10mg tablet, provides 2.5mg

• ½ 10mg tablet, provides 5mg

• ¼ 20mg tablet, provides 5mg 

Advanced: 5mg-20mg, achievable by:

• ½ 10mg tablet, or ¼ 20mg tablet, provides 5mg

• 1 full 10mg tablet or ½ 20mg provides 10 mg

• ¾ 20mg tablet provides 15mg

• 1 full 20mg tablet, provides 20mg 

Remember when you take kratom in higher doses to take breaks. High doses aren't meant for continual use. Consult your medical professional, especially if you are on medications.

Do not take alkaloids mitragynine and 7-hydroxymitragynine with alcohol, sedatives, or recreational drugs.

7-Hydro Chewable Kratom Tablets Product Details

7-Hydroxymitragynine tablets (←You can order here!) come in two strengths and several product package quantities for your convenience: 

10mg 7-Hydroxymitragynine Tablets 

• 3 count

• 10 count

• 20 count

• 50 count

20mg 7-Hydroxymitragynine Tablets 

• 3 count

• 10 count

• 20 count

• 50 count
  
  

7-Hydro Liquid Kratom Shots

Liquid kratom shots are the way to go for fast onset of your 7-hydroxymitragynine effects. Our 7-Hydroxy Shots (←You can order here!) come in one compact bottle with 30mg of high-powered support.

No, you shouldn't drink the whole bottle. It's not like one of those little energy shot bottles you see in gas stations and grocery stores, and shouldn't be taken with the same casual flair. Getting the dosing right is easily done with a measuring spoon.

Each bottle contains two 15 mg doses, therefore:

• Beginners: Not recommended.  

• Moderates: ¼ bottle or less. This equates to three teaspoons or one tablespoon, 7.5mg.

• Advanced or occasional high-dose support: ½ bottle. This equates to one fluid ounce, or two tablespoons, 15mg.

7-Hydroxymitragynine Safe Use Tips

We've come a long way in kratom use from when leaves were chewed right in the fields of Southeast Asia. Many people are skipping the kratom teas and opting for fast and easy. Here are some great tips to help you use kratom with added 7-hydroxymitragynine. Without overdoing it, experiencing adverse effects (like tummy troubles) or risking withdrawal symptoms, which can happen with prolonged or heavy doses of kratom extracts:

1. 7-OH kratom may be too strong for you. That's ok. There are MIT-based, full-spectrum kratom products that may induce stimulatory effects at small doses, and relief at higher ones. These types of kratom may work better for your type of metabolism.

2. Always refer to your product packaging on any 7-OH products you plan to take.

3. Adhere to product recommendations for dosing, but not mindlessly. Just because 'one dose' equals a certain amount, doesn't mean you will need that much. Use mindful doses.

4. Remember, the highest dose is not always your optimal dose. Taking too-high doses could lead to sedative effects.

5. Do not exceed dosing recommendations for a particular product. Dosing recommendations are set with your safety in mind. 

Real Botanicals 7-hydroxymitragynine Dose Guides 

Scientists continue to study the effects of kratom. Increasing our scientific understanding of kratom can help us to better understand the complexities of kratom use. The above 7-hydroxymitragynine dose guidelines are only a starting point. Make sure to factor in your sensitivity to kratom alkaloids, your metabolism, and your personal health. 

Real Botanicals makes your wellness, health, safety, and your kratom experience our top priorities. By focusing on product purity and perfection, and providing transparency, we're happy to provide top-tier kratom support for those who need it. 

For more information on kratom dosing, see: Understanding Kratom Extract vs Powder: Kratom Dosage & Usage Guide.